Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC9588625 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Jin Yan Y Li Yang Y Eisenmann Eric D ED Figg William D WD Baker Sharyn D SD Sparreboom Alex A Hu Shuiying S
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20220827
Glycochenodeoxycholate-3-sulfate (GCDCA-S) and chenodeoxycholate-24-glucuronide (CDCA-24G) are bile acid metabolites that potentially serve as endogenous biomarkers for drug-drug interactions mediated by the hepatic uptake transporters OATP1B1 and OATP1B3. We developed and validated a novel UHPLC-MS/MS method for the quantitative determination of GCDCA-S and CDCA-24G in mouse and human plasma with a lower limit of quantitation of 0.5 ng/mL. Chromatographic separation was achieved on an Accucore ...[more]