Ontology highlight
ABSTRACT:
SUBMITTER: Su H
PROVIDER: S-EPMC9588640 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Su Hua H Yang Fei F Fu Rao R Trinh Brittney B Sun Nina N Liu Junlai J Kumar Avi A Baglieri Jacopo J Siruno Jeremy J Le Michelle M Li Yuhan Y Dozier Stephen S Nair Ajay A Filliol Aveline A Sinchai Nachanok N Rosenthal Sara Brin SB Santini Jennifer J Metallo Christian M CM Molina Anthony A Schwabe Robert F RF Lowy Andrew M AM Brenner David A DA Sun Beicheng B Karin Michael M
Nature 20221005 7931
Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic, aggressive cancer that frequently progresses and spreads by metastasis to the liver<sup>1</sup>. Cancer-associated fibroblasts, the extracellular matrix and type I collagen (Col I) support<sup>2,3</sup> or restrain the progression of PDAC and may impede blood supply and nutrient availability<sup>4</sup>. The dichotomous role of the stroma in PDAC, and the mechanisms through which it influences patient survival and enables desmopla ...[more]