Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis.

ABSTRACT:

Background

Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbidity and mortality worldwide, which beckons new solutions. Host-microbial interactions with a depletion of Faecalibacterium prausnitzii in CKD are reported. However, the mechanisms about if and how F prausnitzii can be used as a probiotic to treat CKD remains unknown.

Methods

We evaluated the microbial compositions in 2 independent CKD populations for any potential probiotic. Next, we investigated if supplementation of such probiotic in a mouse CKD model can restore gut-renal homeostasis as monitored by its effects on suppression on renal inflammation, improvement in gut permeability and renal function. Last, we investigated the molecular mec

SUBMITTER: Li HB 

PROVIDER: S-EPMC9588706 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature