The Effects of Histone H2B Ubiquitylations on the Nucleosome Structure and Internucleosomal Interactions.

ABSTRACT: Eukaryotic gene compaction takes place at multiple levels to package DNA to chromatin and chromosomes. Two of the most fundamental levels of DNA packaging are at the nucleosome and dinucleosome stacks. The nucleosome is the basic gene-packing unit and is composed of DNA wrapped around a histone core. Nucleosomes stack with one another for further compaction of DNA. The first stacking step leads to dinucleosome formation, which is driven by internucleosomal interactions between various parts of two nucleosomes. Histone proteins are rich targets for post-translational modifications, some of which affect the structure of the nucleosome and the interactions between nucleosomes. These effects are often implicated in the regulation of various genomic transactions. In particular, histone H2B ubiq

SUBMITTER: Sengupta B 

PROVIDER: S-EPMC9588709 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature