Lung and Plasma Metabolome in HIV-Associated Obstructive Lung Disease.

ABSTRACT:

Background

HIV is a risk factor for obstructive lung disease (OLD), independent of smoking. We used mass spectrometry (MS) approaches to identify metabolomic biomarkers that inform mechanistic pathogenesis of OLD in persons with HIV (PWH).

Methods

We obtained bronchoalveolar lavage fluid (BALF) samples from 52 PWH, in case:control (+OLD/-OLD) pairs matched on age, smoking status, and antiretroviral treatment. Four hundred nine metabolites from 8 families were measured on BALF and plasma samples using a MS-based Biocrates platform. After filtering metabolites with a high proportion of missing values and values below the level of detection, we performed univariate testing using paired t tests followed by false discovery rate corrections. We used distance-weighted discriminatio

SUBMITTER: Wendt CH 

PROVIDER: S-EPMC9588728 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature