Interstitial Photothermal Therapy Generates Durable Treatment Responses in Neuroblastoma.

ABSTRACT: Photothermal therapy (PTT) represents a promising modality for tumor control typically using infrared light-responsive nanoparticles illuminated by a wavelength-matched external laser. However, due to the constraints of light penetration, PTT is generally restricted to superficially accessible tumors. With the goal of extending the benefits of PTT to all tumor settings, interstitial PTT (I-PTT) is evaluated by the photothermal activation of intratumorally administered Prussian blue nanoparticles with a laser fiber positioned interstitially within the tumor. This interstitial fiber, which is fitted with a terminal diffuser, distributes light within the tumor microenvironment from the "inside-out" as compared to from the "outside-in" traditionally observed during superficially administered P

SUBMITTER: Ledezma DK 

PROVIDER: S-EPMC9588730 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature