Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8⁺ T Cells.

ABSTRACT: Lung tissue-resident memory T cells are crucial mediators of cellular immunity against respiratory viruses; however, their gradual decline hinders the development of T cell-based vaccines against respiratory pathogens. Recently, studies using adenovirus (Ad)-based vaccine vectors have shown that the number of protective lung-resident CD8⁺ T_RMs can be maintained long term. In this article, we show that immunization of mice with a replication-deficient Ad serotype 5 expressing influenza (A/Puerto Rico/8/34) nucleoprotein (AdNP) generates a long-lived lung T_RM pool that is transcriptionally indistinct from those generated during a primary influenza infection. In addition, we demonstrate that CD4⁺ T cells contribute to the long-term maintenance of Ad

SUBMITTER: Lobby JL 

PROVIDER: S-EPMC9588742 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature