Association between recent pregnancy or hormonal contraceptive exposure and outcome of desmoid-type fibromatosis.

ABSTRACT:

Background

The role of both hormonal contraception and pregnancy on the outcomes of desmoid-type fibromatosis (DF) is debatable.

Materials and methods

In the present study, we selected female patients of childbearing age from the prospective ALTITUDES cohort. The primary study endpoint was event-free survival (EFS), with an event defined as relapse or progression. We estimated the risk of events according to the use of hormonal contraception [estrogen-progestin (EP) and progestin] and pregnancy status using multivariate time-dependent models, controlling for major confounders.

Results

A total of 242 patients (median age, 34.7 years) were included in the present study. The abdominal wall was the most common tumor site (51%). Patients were managed by active surveillance

SUBMITTER: Debaudringhien M 

PROVIDER: S-EPMC9588892 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature