Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases.

ABSTRACT:

Background

Functional vitamin B12 deficiency is common in cardiovascular diseases (CVDs), such as heart failure and myocardial infarction. Methylmalonic acid (MMA) is a specific and sensitive marker of vitamin B12 deficiency. However, there are scarce data in regard to the relationship between MMA and CVDs.

Materials and methods

In this cross-sectional study, we analyzed data of 5,313 adult participants of the National Health and Nutrition Examination Survey (NHANES) 2013-2014. Associations between MMA and other variables were assessed with linear regression models. Univariable and multivariable logistic regression models were employed to explore the association between MMA and CVDs.

Results

The weighted prevalence of CVDs was 8.8% in the general population of the USA

SUBMITTER: Wang X 

PROVIDER: S-EPMC9588910 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature