Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction.

ABSTRACT:

Background

Mechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little direct evidence of preservation of functional myocardium.

Aim

The aim of the study was to investigate tissue remodeling in the infarcted heart following human embryonic stem cell-derived endothelial cell product (hESC-ECP) therapy.

Materials and methods

Following coronary artery ligation (CAL) to induce cardiac ischemia, we investigated infarct size at 1 day post-injection in media-injected controls (CALM, n = 11), hESC-ECP-injected mice (CALC, n = 10), and dead hESC-ECP-injected mice (CALD, n = 6); echocardiography-bas

SUBMITTER: Spiroski AM 

PROVIDER: S-EPMC9588936 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature