Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis.

ABSTRACT: Osseointegration seems to be a foreign body reaction equilibrium due to the complicated interactions between the immune and skeletal systems. The heterogeneity of the osteoimmune microenvironment in the osseointegration of implant materials remains elusive. Here, a single-cell study involving 40043 cells is conducted, and a total of 10 distinct cell clusters are identified from five different groups. A preliminary description of the osteoimmune microenvironment revealed the diverse cellular heterogeneity and dynamic changes modulated by implant properties. The increased immature neutrophils, Ly6C ⁺ CCR2^hi monocytes, and S100a8^hi macrophages induce an aggressive inflammatory response and eventually lead to the formation of fibrous capsule around the stainles

SUBMITTER: Li J 

PROVIDER: S-EPMC9588995 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature