Impact of changes at the Candida albicans cell surface upon immunogenicity and colonisation in the gastrointestinal tract.

ABSTRACT: The immunogenicity of Candida albicans cells is influenced by changes in the exposure of microbe-associated molecular patterns (MAMPs) on the fungal cell surface. Previously, the degree of exposure on the C. albicans cell surface of the immunoinflammatory MAMP β-(1,3)-glucan was shown to correlate inversely with colonisation levels in the gastrointestinal (GI) tract. This is important because life-threatening systemic candidiasis in critically ill patients often arises from translocation of C. albicans strains present in the patient's GI tract. Therefore, using a murine model, we have examined the impact of gut-related factors upon β-glucan exposure and colonisation levels in the GI tract. The degree of β-glucan exposure was examined by imaging flow cytometry of C.

SUBMITTER: Avelar GM 

PROVIDER: S-EPMC9589014 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature