The nature of the fungal cargo induces significantly different temporal programmes of macrophage phagocytosis.

ABSTRACT: Phagocytosis is an essential component of our immune defence against fungal pathogens. Differences in the dynamics of phagocyte migration, recognition, uptake and phagolysosome maturation are dependent on the characteristics of the fungal cargo, and in particular to differences in cell wall composition and cellular morphology. However, studies that have focused on phagocyte interactions with individual fungal species have not enabled comparisons in the kinetics of these interactions to be made between these different species. We therefore used live cell video microscopy to examine the temporal dynamics of phagocytosis for a range of fungal cargoes by thioglycollate-elicited peritoneal macrophages from C57BL/6 mice. Uniform populations of macrophages were challenged at the same time with ye

SUBMITTER: Alonso MF 

PROVIDER: S-EPMC9589029 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature