Functional topologies of spatial cognition predict cognitive and motor progression in Parkinson's.

ABSTRACT:

Background

Spatial cognition deteriorates in Parkinson's disease (PD), but the neural substrates are not understood, despite the risk for future dementia. It is also unclear whether deteriorating spatial cognition relates to changes in other cognitive domains or contributes to motor dysfunction.

Objective

This study aimed to identify functional connectivity abnormalities in cognitively normal PD (PDCN) in regions that support spatial cognition to determine their relationship to interfacing cognitive functions and motor disability, and to determine if they predict cognitive and motor progression 2 years later in a PDCN subsample.

Methods

Sixty-three PDCN and 43 controls underwent functional MRI while judging whether pictures, rotated at various angles, depicted the lef

SUBMITTER: Harrington DL 

PROVIDER: S-EPMC9589098 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature