Synonymous nucleotide changes drive papillomavirus evolution.
Ontology highlight
ABSTRACT:
SUBMITTER: King KM
PROVIDER: S-EPMC9589209 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Synonymous nucleotide changes drive papillomavirus evolution.
King Kelly M KM Rajadhyaksha Esha Vikram EV Tobey Isabelle G IG Van Doorslaer Koenraad K
Tumour virus research 20221017
Papillomaviruses have been evolving alongside their hosts for at least 450 million years. This review will discuss some of the insights gained into the evolution of this diverse family of viruses. Papillomavirus evolution is constrained by pervasive purifying selection to maximize viral fitness. Yet these viruses need to adapt to changes in their environment, e.g., the host immune system. It has long been known that these viruses evolved a codon usage that doesn't match the infected host. Here w ...[more]
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2022-06-24 | GSE206526 | GEO