Glucocorticoid receptor dysregulation underlies 5-HT_2AR-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.

ABSTRACT: Prenatal environmental insults increase the risk of neurodevelopmental psychiatric conditions in the offspring. Structural modifications of dendritic spines are central to brain development and plasticity. Using maternal immune activation (MIA) as a rodent model of prenatal environmental insult, previous results have reported dendritic structural deficits in the frontal cortex. However, very little is known about the molecular mechanism underlying MIA-induced synaptic structural alterations in the offspring. Using prenatal (E12.5) injection with polyinosinic-polycytidylic acid potassium salt as a mouse MIA model, we show here that upregulation of the serotonin 5-HT_2A receptor (5-HT_2AR) is at least in part responsible for some of the effects of prenatal insults on fron

SUBMITTER: Saunders JM 

PROVIDER: S-EPMC9589215 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature