Addictive behavior and incident gallstone disease: A dose-response meta-analysis and Mendelian randomization study.

ABSTRACT:

Background

Previous studies have suggested associations between addictive behavior and gallstone disease (GSD) risk, yet conflicting results exist. It also remains unclear whether this association is causal or due to confounding or reverse associations. The present study aims to systematically analyze the epidemiological evidence for these associations, as well as estimate the potential causal relationships using Mendelian randomization (MR).

Methods

We analyzed four common addictive behaviors, including cigarette smoking, alcohol intake, coffee, and tea consumption (N = 126,906-4,584,729 participants) in this meta-analysis based on longitudinal studies. The two-sample MR was conducted using summary data from genome-wide associations with European ancestry (up to 1.2

SUBMITTER: Bai Y 

PROVIDER: S-EPMC9589252 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature