Ruthenium polypyridine complexes with triphenylamine groups as antibacterial agents against Staphylococcus aureus with membrane-disruptive mechanism.

ABSTRACT: Due to the emergence and wide spread of methicillin-resistant Staphylococcus aureus, the treatment of this kind of infection becomes more and more difficult. To solve the problem of drug resistance, it is urgent to develop new antibiotics to avoid the most serious situation of no drug available. Three new Ru complexes [Ru (dmob)₂PMA] (PF6)₂ (Ru-1) [Ru (bpy)₂PMA] (PF6)₂ (Ru-2) and [Ru (dmb)₂PMA] (PF6)₂ (Ru-3) (dmob = 4,4'-dimethoxy-2,2'-bipyridine, bpy = 2,2'-bipyridine, dmb = 4,4'-dimethyl-2,2'-bipyridine and PMA = N-(4-(1H-imidazo [4,5-f] [1,10] phenanthrolin-2-yl) -4-methyl-N-(p-tolyl) aniline) were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The detailed molecular structure of

SUBMITTER: Jiang L 

PROVIDER: S-EPMC9589286 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature