Assessment of mesenchymal stem/stromal cell-based therapy in K/BxN serum transfer-induced arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial hyperplasia and cartilage/bone destruction with systemic comorbidities. Despite advances in understanding the aetiology of RA and novel biologic drugs, a substantial number of individuals with RA remain intolerant or resistant to these therapies. In this context, mesenchymal stem/stromal cell (MSC)-based therapy has emerged as an innovative therapeutic alternative to address unresolved treatment issues for patients with RA thanks to the immunomodulatory properties of these cells. The majority of preclinical studies in MSC-based therapy have been conducted using the well-known collagen-induced arthritis (CIA) mouse model however due to its low incidence, the mouse strain restriction and the prolonged induction phas

SUBMITTER: Lopez-Santalla M 

PROVIDER: S-EPMC9589432 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature