The impact of harmonization on radiomic features in Parkinson's disease and healthy controls: A multicenter study.

ABSTRACT: Radiomics is a challenging development area in imaging field that is greatly capturing interest of radiologists and neuroscientists. However, radiomics features show a strong non-biological variability determined by different facilities and imaging protocols, limiting the reproducibility and generalizability of analysis frameworks. Our study aimed to investigate the usefulness of harmonization to reduce site-effects on radiomics features over specific brain regions. We selected T1-weighted magnetic resonance imaging (MRI) by using the MRI dataset Parkinson's Progression Markers Initiative (PPMI) from different sites with healthy controls (HC) and Parkinson's disease (PD) patients. First, the investigation of radiomics measure discrepancies were assessed on healthy brain regions-of-i

SUBMITTER: Tafuri B 

PROVIDER: S-EPMC9589497 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature