Predicting compound amenability with liquid chromatography-mass spectrometry to improve non-targeted analysis.

ABSTRACT: With the increasing availability of high-resolution mass spectrometers, suspect screening and non-targeted analysis are becoming popular compound identification tools for environmental researchers. Samples of interest often contain a large (unknown) number of chemicals spanning the detectable mass range of the instrument. In an effort to separate these chemicals prior to injection into the mass spectrometer, a chromatography method is often utilized. There are numerous types of gas and liquid chromatographs that can be coupled to commercially available mass spectrometers. Depending on the type of instrument used for analysis, the researcher is likely to observe a different subset of compounds based on the amenability of those chemicals to the selected experimental techniques and equipment.

SUBMITTER: Lowe CN 

PROVIDER: S-EPMC9589520 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature