Gut bacteria alleviate smoking-related NASH by degrading gut nicotine.

ABSTRACT: Tobacco smoking is positively correlated with non-alcoholic fatty liver disease (NAFLD)^1-5, but the underlying mechanism for this association is unclear. Here we report that nicotine accumulates in the intestine during tobacco smoking and activates intestinal AMPKα. We identify the gut bacterium Bacteroides xylanisolvens as an effective nicotine degrader. Colonization of B. xylanisolvens reduces intestinal nicotine concentrations in nicotine-exposed mice, and it improves nicotine-exacerbated NAFLD progression. Mechanistically, AMPKα promotes the phosphorylation of sphingomyelin phosphodiesterase 3 (SMPD3), stabilizing the latter and therefore increasing intestinal ceramide formation, which contributes to NAFLD progression to non-alcoholic steatohepatitis (NASH). Our results esta

SUBMITTER: Chen B 

PROVIDER: S-EPMC9589931 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature