Natural products targeting the ATR-CHK1 signaling pathway in cancer therapy.

ABSTRACT: Cancer is one of the most severe medical conditions in the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer requires novel efficacious treatment modalities. Natural remedies offer feasible alternative options against malignancy in contrast to available synthetic medication. Selective killing of cancer cells is privileged mainstream in cancer treatment, and targeted therapy represents the new tool with the potential to pursue this aim. The discovery of innovative therapies targeting essential components of DNA damage signaling and repair pathways such as

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC9590097 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature