Predictors and Moderators of Relapse in Children and Adolescents With Major Depressive Disorder.

ABSTRACT:

Objective

To identify predictors and moderators of relapse during continuation treatment among depressed youth randomly assigned to fluoxetine or placebo.

Methods

Potential predictors and moderators of relapse that were identified by a literature review were examined in 102 youth (aged 7-18 years), diagnosed with major depressive disorder as defined by DSM-IV criteria, who were considered responders after 12 weeks of fluoxetine treatment (acute phase). This randomized controlled trial was conducted from June 2000 through October 2005. Each candidate predictor and moderator was evaluated with a multiple logistic regression model to examine the main and interaction effects of 12 weeks of continuation treatment on relapse status (at week 24) while controlling for age, sex, and

SUBMITTER: Kennard BD 

PROVIDER: S-EPMC9590113 | biostudies-literature | 2018 Mar/Apr

REPOSITORIES: biostudies-literature