Negatively-charged supported lipid bilayers regulate neuronal adhesion and outgrowth.

ABSTRACT: One of the main challenges in neuroelectronics is the implementation of electronic platforms able to secure a tight coupling with neuronal cells and achieve an optimal signal to noise ratio during stimulation/recording of electrophysiological activity. In this context, supported lipid bilayers (SLBs), recapitulating the structure and the dynamicity of the biological plasma membrane, offer a promising biomimetic approach to trick cells to recognize a device as part of their native environment, tightening the cell-chip coupling. Among possible functionalization strategies used to improve cell adhesion on SLBs, the modification of the bilayer surface charge has been exploited to enhance the electrostatic interaction between the artificial membrane and its biological counterpart. In this work,

SUBMITTER: Ausilio C 

PROVIDER: S-EPMC9590245 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature