Proximity-enhanced synthesis of DNA-peptide-DNA triblock molecules.

ABSTRACT: We report a proximity-enhanced method to synthesize a peptide flanked by two different oligonucleotide handles. Our method relies on sequential bioorthogonal reactions, and partial hybridization of the second handle to the first. We demonstrate the synthesis of a protease-responsive DNA "latch" and a cyclic bioactive peptide using this method.

SUBMITTER: MacCulloch T 

PROVIDER: S-EPMC9590276 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature