Disrupting the medial prefrontal cortex with designer receptors exclusively activated by designer drug alters hippocampal sharp-wave ripples and their associated cognitive processes.

ABSTRACT: The hippocampus and medial prefrontal cortex (mPFC) interact during a myriad of cognitive processes including decision-making and long-term memory consolidation. Exactly how the mPFC and hippocampus interact during goal-directed decision-making remains to be fully elucidated. During periods of rest, bursts of high-frequency oscillations, termed sharp-wave ripple (SWR), appear in the local field potential. Impairing SWRs on the maze or during post-learning rest can interfere with memory-guided decision-making and memory consolidation. We hypothesize that the hippocampus and mPFC bidirectionally interact during SWRs to support memory consolidation and decision-making. Rats were trained on the neuroeconomic spatial decision-making task, Restaurant Row, to make serial stay-skip decisions where

SUBMITTER: Schmidt B 

PROVIDER: S-EPMC9590403 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature