Plasma Lipidomic Subclasses and Risk of Hypertension in Middle-Aged and Elderly Chinese.

ABSTRACT: While disrupted lipid metabolism is a well-established risk factor for hypertension in animal models, the links between various lipidomic signatures and hypertension in human studies remain unclear. We aimed to examine associations between plasma lipidomic profiles and prevalence of hypertension among 2248 community-living Chinese aged 50-70 years. Hypertension was defined according to 2020 International Society of Hypertension global hypertension practice guidelines and 2018 Chinese guidelines. In total, 728 plasma lipidomic species were profiled using high-coverage targeted lipidomics. After multivariate adjustment, including lifestyle, body mass index, blood lipids, and sodium intake, 110 metabolites from nine lipidomic subclasses showed significant associations with hypertension, among

SUBMITTER: Niu Z 

PROVIDER: S-EPMC9590468 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature