Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury.

ABSTRACT:

Background

Genetic variants in apolipoprotein L1 (APOL1), a protein that protects humans from infection with African trypanosomes, explain a substantial proportion of the excess risk of chronic kidney disease affecting individuals with sub-Saharan ancestry. The mechanisms by which risk variants damage kidney cells remain incompletely understood. In preclinical models, APOL1 expressed in podocytes can lead to significant kidney injury. In humans, studies in kidney transplant suggest that the effects of APOL1 variants are predominantly driven by donor genotype. Less attention has been paid to a possible role for circulating APOL1 in kidney injury.

Methods

Using liquid chromatography-tandem mass spectrometry, the concentrations of APOL1 were measured in plasma and urine from pa

SUBMITTER: Andrews M 

PROVIDER: S-EPMC9591058 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature