The Na⁺/K⁺ pump dominates control of glycolysis in hippocampal dentate granule cells.

ABSTRACT: Cellular ATP that is consumed to perform energetically expensive tasks must be replenished by new ATP through the activation of metabolism. Neuronal stimulation, an energetically demanding process, transiently activates aerobic glycolysis, but the precise mechanism underlying this glycolysis activation has not been determined. We previously showed that neuronal glycolysis is correlated with Ca²⁺ influx, but is not activated by feedforward Ca²⁺ signaling (Díaz-García et al., 2021a). Since ATP-powered Na⁺ and Ca²⁺ pumping activities are increased following stimulation to restore ion gradients and are estimated to consume most neuronal ATP, we aimed to determine if they are coupled to neuronal glycolysis activation. By using two-photon imaging of fl

SUBMITTER: Meyer DJ 

PROVIDER: S-EPMC9592084 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature