Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion.

ABSTRACT: Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection. Improved graft preservation may expand transplantable graft numbers and enhance posttransplant outcomes. Superior transplant outcomes have recently been demonstrated in clinical trials using machine perfusion to preserve the liver. We hypothesized that machine perfusion preservation of intestinal allografts could be achieved and allow for transplantation in a porcine model.

Methods

Using a translational porcine model, we developed a device for intestinal perfusion. Intestinal samples were collected at the time of organ procurement, and after 6 h of machine perfusion for gross and histologic evaluati

SUBMITTER: Abraham N 

PROVIDER: S-EPMC9592306 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature