CXCL2 acts as a prognostic biomarker and associated with immune infiltrates in stomach adenocarcinoma.

ABSTRACT:

Background

STAD ranked 5th most common in the incidence of malignant tumors and 3rd most common in the death rate of cancer worldwide. CXC chemokines affect the biological progress of various tumors, resulting in therapeutic failure. The role of CXCL2 in STAD was still a mystery.

Methods

The expression, prognostic value, and clinical function of CXCL2 were analyzed using several online bioinformatics tools and clinical tissues.

Results

CXCL2 level was significantly upregulated in STAD tissues. Strong correlation was obtained between CXCL2 level and immune cells as well as immune biomarkers. High CXCL2 expression in STAD was correlated with a favorable prognosis. Further analysis revealed that CXCL2, pTNM stage and age were independent factors affecting the prognosis o

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9592451 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature