An updated systematic review of the association between the TLR4 polymorphism rs4986790 and cancers risk.

ABSTRACT:

Background

Toll-like receptor 4 (TLR4) is a lipopolysaccharide receptor that may influence tumor progression through inflammatory response and immune response. This complex process mainly occurs within cells. The correlation between TLR4 and neoplasms has been of great interest, but discrepancies remain.

Methods

We analyze the literature retrieved from five databases (Web of Science, PubMed, Embase, CNKI, and Wan Fang) to assess the intensity of association using odds ratio (ORs) and 95% confidence intervals (95% CI). Meta-regression and subgroup analysis were utilized to find sources of heterogeneity. Publication bias is estimated using contour-enhanced funnel plots, Begg's test, and Egger's test, and we implemented sensitivity analysis to clarify the reliability of the out

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC9592503 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature