Establishment of fetomaternal tolerance through glycan-mediated B cell suppression.

ABSTRACT: Discrimination of self from non-self is fundamental to a wide range of immunological processes¹. During pregnancy, the mother does not recognize the placenta as immunologically foreign because antigens expressed by trophoblasts, the placental cells that interface with the maternal immune system, do not activate maternal T cells². Currently, these activation defects are thought to reflect suppression by regulatory T cells³. By contrast, mechanisms of B cell tolerance to trophoblast antigens have not been identified. Here we provide evidence that glycan-mediated B cell suppression has a key role in establishing fetomaternal tolerance in mice. B cells specific for a model trophoblast antigen are strongly suppressed through CD22-LYN inhibitory signalling, which

SUBMITTER: Rizzuto G 

PROVIDER: S-EPMC9592526 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature