Brain-derived neurotrophic factor Val66Met and neuropsychological functioning after early childhood traumatic brain injury.

ABSTRACT:

Objective

The present study examined the differential effect of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on neuropsychological functioning in children with traumatic brain injury (TBI) relative to orthopedic injury (OI).

Methods

Participants were drawn from a prospective, longitudinal study of children who sustained a TBI (n = 69) or OI (n = 72) between 3 and 7 years of age. Children completed a battery of neuropsychological measures targeting attention, memory, and executive functions at four timepoints spanning the immediate post-acute period to 18 months post-injury. Children also completed a comparable age-appropriate battery of measures approximately 7 years post-injury. Parents rated children's dysexecutive behaviors at all timep

SUBMITTER: Treble-Barna A 

PROVIDER: S-EPMC9592678 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature