SARS-CoV-2 Mutations Responsible for Immune Evasion Leading to Breakthrough Infection.

ABSTRACT:

Background and objectives

India had faced a devastating second outbreak of COVID-19 infection, in which a majority of the viral sequences were found to be of the B.1.617.2 lineage (Delta-variant). While India and the world focused on vaccination, reports of vaccine-immunity evasion by the virus, termed "breakthrough cases", emerged worldwide. Our study was focused on the primary objective to identify the mutations associated with breakthrough infections SARS-CoV-2.

Methods

In our study, we extracted the SARS-CoV-2 RNA (ribonucleic acid) from reverse transcription-polymerase chain reaction (RT-PCR) positive COVID-19 patients, and 150 random samples were sent for sequencing to the Centre for Cellular & Molecular Biology, Hyderabad. Whole genome sequences of 150 SARS-CoV-2 vira

SUBMITTER: Sahni C 

PROVIDER: S-EPMC9592688 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature