Single-cell sequencing reveals the cell map and transcriptional network of sporadic vestibular schwannoma.

ABSTRACT: In this study, based on three tumor samples obtained from patients with sporadic vestibular schwannoma, 32,011 cells were obtained by single-cell transcriptome sequencing, and 22,309 high-quality cells were obtained after quality control and double cells removal. Then, 18 cell clusters were obtained after cluster analysis, and each cluster was annotated as six types of cells. Afterward, an in-depth analysis was conducted based on the defined six cell clusters, including characterizing the functional characteristics of each cell subtype, describing the cell development and differentiation pathway, exploring the interaction between cells, and analyzing the transcriptional regulatory network within the clusters. Based on these four dimensions, various types of cells in sporadic vestibular sch

SUBMITTER: Yidian C 

PROVIDER: S-EPMC9592810 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature