Characterization of immune features and immunotherapy response in subtypes of hepatocellular carcinoma based on mitophagy.

ABSTRACT: Mitophagy is suggested to be involved in tumor initiation and development; however, mitophagy heterogeneity in hepatocellular carcinoma (HCC) and its association with immune status and prognosis remain unclear. Differentially expressed genes (DEGs) were identified using expression profiles acquired from The Cancer Genome Atlas (TCGA). Mitophagy-related subtypes were identified using the ConsensusClusterPlus software. The differences in prognosis, clinical characteristics, and immune status, including immune cell infiltration, immune function, immune-checkpoint gene expression, and response to immunotherapy, were compared between subtypes. A mitophagy-related gene signature was constructed by applying least absolute shrinkage and selection operator regression to the TCGA cohort. The Interna

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9592915 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature