Microelectrode arrays, electrosynthesis, and the optimization of signaling on an inert, stable surface.

ABSTRACT: Microelectrode arrays are powerful tools for monitoring binding interactions between small molecules and biological targets. In most cases, molecules to be studied using such devices are attached directly to the electrodes in the array. Strategies are in place for calibrating signaling studies utilizing the modified electrodes so that they can be quantified relative to a positive control. In this way, the relative binding constants for multiple ligands for a receptor can potentially be determined in the same experiment. However, there are applications of microelectrode arrays that require stable, tunable, and chemically inert surfaces on the electrodes. The use of those surfaces dictate the use of indirect detection methods that are dependent on the nature of the stable surface used and th

SUBMITTER: Drayton-White K 

PROVIDER: S-EPMC9592966 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature