Iron overload accelerated lipid metabolism disorder and liver injury in rats with non-alcoholic fatty liver disease

ABSTRACT:

Background/aims

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. Iron overload has been implicated in chronic non-communicable liver diseases, but its relationship with NAFLD remains unclear. This study aimed to investigate the underlying roles of iron overload in the development of NAFLD.

Methods

Male Sprague Dawley rats were fed with a high-fat diet (HFD) and/or iron for 8, 12, and 20 weeks. Some rats fed with HFD plus iron also received intraperitoneal injection of deferoxamine (DFO) for 8 weeks. Liver steatosis, lipid metabolism and injury were evaluated.

Results

A NAFLD model, including typical liver steatosis, was established by feeding rats with a HFD, while iron overload alone is not enough to induce severe NAF

SUBMITTER:  

PROVIDER: S-EPMC9593083 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature