Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study.

ABSTRACT:

Background

After initiating antiretroviral therapy (ART), approximately 25% of people with HIV (PWH) may develop Immune Reconstitution Inflammatory Syndrome (IRIS), which is associated with increased morbidity and mortality. Several reports have demonstrated that low haemoglobin (Hb) levels are a risk factor for IRIS. To what extent the severity of anaemia contributes to the risk of IRIS and/or death is still insufficiently explored.

Methods

We investigated both the presence and severity of anaemia in PWH in a multinational cohort of ART-na..ve patients. A large panel of plasma biomarkers was measured pre-ART and patients were followed up for 6 months. IRIS or deaths during this period were considered as outcomes. We performed multidimensional analyses, logistic regression,

SUBMITTER: Ara Jo-Pereira M 

PROVIDER: S-EPMC9593179 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature