Interaction between MTNR1B polymorphisms and lifestyle intervention on pregnancy outcomes

ABSTRACT: Abstract

Background

Interactions between polymorphisms of the melatonin receptor 1B gene (MTNR1B) and lifestyle intervention for gestational diabetes have been described. Whether these are specific for physical activity or healthy eating intervention is unknown.

Objectives

To assess the interaction between MTNR1B rs10830962 and rs10830963 polymorphisms and lifestyle interventions during pregnancy.

Methods

Women with a BMI of ≥ 29 kg/m2 (n = 436) received counseling on healthy eating (HE), physical activity (PA) or both. The control group received usual care. The analysis had a factorial design with comparison of HE versus no HE and PA versus no PA. Maternal outcomes at 24-28 weeks were gestational weight gain (GWG), maternal fasting glucose, insulin, insulin resi

SUBMITTER: van Poppel M 

PROVIDER: S-EPMC9593569 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature