Positive interaction between ASH and ASK sensory neurons accelerates nociception and inhibits behavioral adaptation.

ABSTRACT: Central and peripheral sensory neurons tightly regulate nociception and avoidance behavior. The peripheral modulation of nociception provides more veridical and instantaneous information for animals to achieve rapid, more fine-tuned and concentrated behavioral responses. In this study, we find that positive interaction between ASH and ASK sensory neurons is essential for the fast-rising phase of ASH Ca²⁺ responses to noxious copper ions and inhibits the adaption of avoiding Cu²⁺. We reveal the underlying neuronal circuit mechanism. ASK accelerates the ASH Ca²⁺ responses by transferring cGMP through gap junctions. ASH excites ASK via a disinhibitory neuronal circuit composed of ASH, AIA, and ASK. Avoidance adaptation depends on the slope rate of the rising phase of ASH Ca²⁺ responses. Thus, in addition to amplitude, sensory kinetics is significant for sensations and behaviors, especially for sensory and behavioral adaptations.

SUBMITTER: Wu JJ 

PROVIDER: S-EPMC9593764 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature