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Copper-catalyzed cross coupling reaction of sulfonyl hydrazides with 3-aminoindazoles† † Electronic supplementary information (ESI) available. CCDC 2203869. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d2ra05956h

ABSTRACT: A novel Cu-catalyzed radical–radical cross coupling reaction of 3-aminoindazoles with sulfonyl hydrazides has been disclosed, enabling the production of diverse 1,3-substituted aminoindazoles in good yields. This methodology is distinguished by readily available starting materials, wide substrate scope and operational simplicity. In addition, a gram-scale reaction has been well demonstrated. A radical–radical cross coupling reaction of 3-aminoindazoles with sulfonyl hydrazides was realized. The strategy afforded the straightforward synthesis of 1,3-substituted aminoindazoles in good yields (up to 96%).

SUBMITTER: Feng G

PROVIDER: S-EPMC9594103 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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