Free water derived by multi-shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease.

ABSTRACT:

Introduction

Free-water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET).

Methods

Seventy-one participants underwent multi-shell diffusion MRI, ¹⁸F-THK5351 PET, ¹¹C-Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) (n = 40) and AD-spectrum group (AD-S) (n = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores.

Results</

SUBMITTER: Nakaya M 

PROVIDER: S-EPMC9594557 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature