Radiological evolution of spinal disease in alkaptonuria and the effect of nitisinone.

ABSTRACT:

Objectives

Ochronotic spondyloarthropathy represents one of the main clinical manifestations of alkaptonuria (AKU); however, prospective data and description of the effect of nitisinone treatment are lacking.

Methods

Patients with AKU aged 25 years or older were randomly assigned to receive either oral nitisinone 10 mg/day (N=69) or no treatment (N=69). Spine radiographs were recorded yearly at baseline, 12, 24, 36 and 48 months, and the images were scored for the presence of intervertebral space narrowing, soft tissue calcifications, vacuum phenomena, osteophytes/hyperostosis and spinal fusion in the cervical, thoracic and lumbosacral segment at each of the time points.

Results

At baseline, narrowing of the intervertebral spaces, the presence of osteophytes/hyperosto

SUBMITTER: Imrich R 

PROVIDER: S-EPMC9594597 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature