Pseudotyping Bacteriophage P2 Tail Fibers to Extend the Host Range for Biomedical Applications.

ABSTRACT: Bacteriophages (phages) represent powerful potential treatments against antibiotic-resistant bacterial infections. Antibiotic-resistant bacteria represent a significant threat to global health, with an estimated 70% of infection-causing bacteria being resistant to one or more antibiotics. Developing novel antibiotics against the limited number of cellular targets is expensive and time-consuming, and bacteria can rapidly develop resistance. While bacterial resistance to phage can evolve, bacterial resistance to phage does not appear to spread through lateral gene transfer, and phage may similarly adapt through mutation to recover infectivity. Phages have been identified for all known bacteria, allowing the strain-selective killing of pathogenic bacteria. Here, we re-engineered the Escher

SUBMITTER: Cunliffe TG 

PROVIDER: S-EPMC9594776 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature