NOVA1 promotes NSCLC proliferation and invasion by activating Wnt/β-catenin signaling.

ABSTRACT:

Background

Neuro-oncological ventral antigen 1 (NOVA1) is a neuron-specific RNA-binding protein which regulates alternative splicing in the developing nervous system. Recent research has found that NOVA1 plays a significant role in carcinogenesis. In this paper, we examine the role of NOVA1 in non-small cell lung cancer (NSCLC) and its underlying molecular mechanisms.

Methods

The expression of NOVA1 in NSCLC was detected by immunohistochemistry and correlations between NOVA1 expression and clinicopathological factors were analyzed by chi-square tests. Kaplan-Meier survival analysis and the Cox regression model were used to evaluate the predictive effect of prognostic factors. Western blotting, Cell Counting Kit-8, colony formation, apoptosis, migration and invasion assays we

SUBMITTER: Qu L 

PROVIDER: S-EPMC9594932 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature