Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway.

ABSTRACT: Background: Medulloblastoma is the most common pediatric malignant tumor in central nervous system. Although its prognosis has been improved enormously by the combination treatments with surgery, radiotherapy, and chemotherapy, it still could progress via invasion and distant dissemination. We aimed to investigate molecular mechanisms of medulloblastoma invasion in the current work. Methods: The gene expression profile of medulloblastoma were analyzed based on the data deposited in Gene Expression Omnibus (GEO) and filtered according to brain specific proteins in the Uniprot. Delta-catenin was identified and further analyzed about its expression and roles in the prognosis of medulloblastoma patient. The function of delta-catenin on cell invasion and migration were inve

SUBMITTER: Hu Y 

PROVIDER: S-EPMC9595215 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature