Poor immune response to coronavirus disease vaccines in decompensated cirrhosis patients and liver transplant recipients.

ABSTRACT:

Background and aims

Recent studies have reported poor humoral immune response to mRNA vaccines in patients with chronic liver disease (CLD). However, the immunogenicity of ChAdOx1 (vector-based) and BBV152 (inactivated virus) vaccines in patients with CLD and liver transplant recipients (LTRs) is unknown. Therefore, we aimed to assess the immunogenicity of ChAdOx1 and BBV152 vaccines in patients with CLD (including cirrhosis patients) and LTRs.

Methods

In this single-center prospective study, consecutive completely vaccinated (ChAdOx1 or BBV152) non-cirrhosis CLD patients, those with cirrhosis, and LTRs were compared with matched healthy controls for anti-spike antibody and cellular response.

Results

Sixty healthy individuals, 50 NCCLD patients, 63 compensated and 50

SUBMITTER: Kulkarni AV 

PROVIDER: S-EPMC9595300 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature